She sits on a number of national and international committees including as a member of the of the South African Immunological Society, chair of the National Expert Committee on Immunology and the current Chair of the Expert Chairs Committee for the National Health Laboratory Service. Internationally, she serves on the executive of the Science and Policy Committee of the International Society of Biological and Environmental Repositories and as the regional ambassador for the Europe, Middle East and Africa region.
Professor Mayne has published and lectured extensively on immunology and pathology. In addition to her work in research and routine immunopathology, Dr Mayne is principal investigator of the CLS biorepository and in this capacity has been involved in investigation of non-communicable diseases as a member of the H3 Africa consortium. Prof Mayne is also involved in a number of research projects examining HIV-associated conditions including HIV-associated malignancies, HIV-associated non-communicable diseases and opportunistic infections including Mycobacterium tuberculosis. Dr Mayne has completed her doctoral thesis in vascular dysfunction in HIV.